Each has at least one handicap that, in any other year, would make it impossible for him to win the nomination.
每一位至少有一个不利条件，如果在其它任何一年里，将使他无法赢得提名。Some of these can be put right, but many are beyond the reach of any reform.
其中某些不利条件可以得到扭转，但还有许多是任何改革都无力改变的。The exact nature of these penalties remains just as contentious as many other details.
这些不利条件也许会像其他计划细节那样引发争议。U. S. Treasury Secretary Timothy Geithner said the U. S. economy is growing in spite of headwinds including the European financial crisis.
美国财政部长盖特纳说，尽管受到了欧洲金融危机等不利条件的影响，但是美国经济持续增长。Her accent will be very much to her disadvantage if she wants to be an actress.
她要是想当演员，她的口音是个很大的不利条件。The first disadvantage was the distance of the North African bases from the heart of Germany.
第一个不利条件是北非与德国心脏地带距离太远。The environmental work means both of taking the advantage of environment for development and overcoming the disadvantage of it.
环境工作有开发利用和保护环境的有利条件及克服和改善环境的不利条件两个方面。You can think of those who struggle even harder than you do, against far greater odds, and with far less to work with than you do.
你也可以想一想另外一些人，他们奋斗得比你还要艰难，面临的不利条件要大得多，而且他们的同伴比你的少得多。Even with such handicaps he could be relied on to run the most prosperous enterprise into the ground.
不过，尽管有种种不利条件，人们还是认为他有能耐把最兴旺的企业办得一败涂地。